| 父源性HLA-A基因与子痫前期相关性的研究 |
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| 引用本文： | 张展,李静,张琳琳,贾莉婷,李辉,王婧彦,琚娟,荣守华.父源性HLA-A基因与子痫前期相关性的研究[J].现代妇产科进展,2010,19(1). |
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| 作者姓名： | 张展 李静 张琳琳 贾莉婷 李辉 王婧彦 琚娟 荣守华 |
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| 作者单位： | 1. 郑州大学第三附属医院检验科,郑州,450052
2. 郑州大学第三附属医院妇产科,郑州,450052 |
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| 基金项目： | 国家自然科学基金，河南省科技厅重点攻关项目，河南省卫生厅重点项目 |
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| 摘 要： | 目的:探讨父源性人类白细胞分化抗原HLA-A基因与子痫前期的相关性。方法:采用序列特异性引物技术(PCR-SSP)对53对子痫前期患者及其配偶和51对正常孕妇及其配偶进行HLA-A等位基因分型,比较其基因频率,并对两组夫妇HLA-A等位基因型别配伍进行比较分析。结果:子痫前期患者和正常晚孕者中检出14个HLA-A等位基因,配偶中检出13个HLA-A等位基因。子痫前期组配偶HLA-A24基因频率显著低于正常晚孕组(P0.05);两组孕妇及其配偶的其它HLA-A基因型别无显著差异。子痫前期组夫妇均携带HLA-A11基因的频率显著高于正常晚孕组(P0.05);子痫前期组妇不携带HLA-A24而夫携带HLA-A24基因的频率显著低于正常晚孕组(P0.05);子痫前期组夫妇均不携带HLA-A24基因的频率显著高于正常晚孕组(P0.05)。结论:夫妇间的某些特定HLA-A基因配伍模式与子痫前期的发病相关。
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| 关 键 词： | 人类白细胞分化抗原 子痫前期 序列特异性引物技术 多态性 |
Research on polymorphism of patrilineal HLA-A in preeclampsia |
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| Zhang Zhan,Li Jing,Zhang Linlin,et al..Research on polymorphism of patrilineal HLA-A in preeclampsia[J].Current Advances In Obstetrics and Gynecology,2010,19(1). |
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| Authors: | Zhang Zhan Li Jing Zhang Linlin |
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| Institution: | Zhang Zhan1,Li Jing2,Zhang Linlin1,et al.1.Department of Clinical Laboratory,2.Department of Obstetrics , Gynecology,The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052 |
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| Abstract: | Objective:To analyze the association between the polymorphism of patrilineal HLA-A genes and preeclampsia.Methods:HLA-A genotyping was performed by polymerase chain reaction sequence-specific primer(PCR-SSP)in 53 preeclampsia patients,51 normal pregnant women and their husbands.Results:The study showed that 14 HLA-A alleles were obtained in preeclamptic patients and normal pregnant women.13 HLA-A alleles were obtained in their husbands.The frequenency of HLA-A24 in husband with preeclampsia group was lower ... |
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| Keywords: | Human leucocyte antigen Pre-eclampsia PCR-SSP Polymorphism |
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