| 秃疮花提取物对CCl4诱导的小鼠急性肝损伤的影响 |
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| 引用本文： | 毛爱红,唐德平,夏晓慧,魏娟,王勤. 秃疮花提取物对CCl4诱导的小鼠急性肝损伤的影响[J]. 兰州大学学报(医学版), 2008, 34(2) |
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| 作者姓名： | 毛爱红 唐德平 夏晓慧 魏娟 王勤 |
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| 作者单位： | 兰州大学,生命科学学院,甘肃,兰州,730000;甘肃省医学科学研究院,甘肃,兰州,730050;兰州大学,生命科学学院,甘肃,兰州,730000 |
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| 摘 要： | 目的 探讨秃疮花提取物(DLE)对CCl4诱导的小鼠急性肝损伤的影响.方法 给予小鼠不同剂量的DLE灌胃,连续10 d.小鼠腹腔注射CCl4造成急性肝损伤,16 h后测定血清谷丙转氨酶(ALT)、谷草转氨酶(AST)活性;制备肝组织匀浆测定丙二醛含量及超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)活性;同时进行肝组织病理观察.结果 与模型组相比,不同剂量的DLE给药组小鼠血清ALT、AST活性显著降低,肝组织匀浆中丙二醛含量显著减少;SOD、GSH-Px活性显著升高;病理切片表明DLE作用后肝组织损伤不同程度减轻,其中剂量为2.0 g生药/kg体重时,肝组织的损伤程度较轻.结论 DLE对CCl4诱导的小鼠急性肝损伤具有很好的保护作用,其作用机制可能与DLE抑制抗氧化酶活性和抗自由基活性有关.
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| 关 键 词： | 秃疮花提取物 四氯化碳 急性肝损伤 保肝作用 |
Protective effects of Dicranostigma leptopodum(Maxim.)Fedde extractives on acute liver injury induced by CCl_4 in mice |
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| MAO Ai-hong TANG De-ping XIA Xiao-hui WEI Juan WANG Qin. Protective effects of Dicranostigma leptopodum(Maxim.)Fedde extractives on acute liver injury induced by CCl_4 in mice[J]. Journal of Lanzhou University (Medical Sciences), 2008, 34(2) |
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| Authors: | MAO Ai-hong TANG De-ping XIA Xiao-hui WEI Juan WANG Qin |
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| Affiliation: | MAO Ai-hong~(1,2) TANG De-ping~1 XIA Xiao-hui~1 WEI Juan~1 WANG Qin~1 (1.School of Life Sciences,Lanzhou University,Lanzhou 730000,China,2.Institute of Medical Sciences,Gansu Province,Lanzhou 730050,China) |
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| Abstract: | Objective To investigate the effects of Dicranostigma leptopodum(Maxim.)Fedde extractives(DLE)on acute liver injury induced by CCla in mice.Methods Acute liver injury of mice was induced by intraperitoneally injection of CC14.DLE-treated group was intragastrically treated with 1.0,2.0 and 4.0 g/kg bodyweight of DLE respectively for 10 days while the control group was intraperitoneally injected with the same volume of olive oil.After 16 hours,the activities of aspartate aminotransferase(AST)and alanine amino... |
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| Keywords: | Dicranostigma leptopodum(Maxim.)Fedde extractives carbon tetrachloride acute liver injury hepatoprotection |
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