应用钛环钉行人工血管旁路术的实验研究

目的　探讨应用钛环钉行人工血管旁路术后人工血管及髂动脉腔表面内皮细胞形态学变化。方法　选用14 只健康雄性恒河猴,用3 mm 直径的ePTFE 人工血管置换左髂总动脉,近端用60 无创缝线吻合,远端用73Ⅱ型血管吻合器吻合。术后4 周,取出吻合口行光镜及电镜检查。结果　钛环钉组血管损伤反应轻,吻合口有完整内膜覆盖;而缝线组损伤反应重,吻合口内膜覆盖不完整,有血栓样组织沉积。结论　钛环钉组吻合口在术后4 周均形成完整的内膜,对预防吻合口早期血栓形成及晚期内膜增生有重要意义

Experimental studies on artificial blood vessel bypass with titanium staplers in macaca

Objective To investigate the morphologic change of the endothelial cells in the surface of the grafts and the iliac artery after artificial blood vessel bypass. Methods Abstract Objective To investigate the morphologic change of the endothelial cells in the surface of the grafts and the iliac artery after artificial blood vessel bypass. Methods Fourteen male healthy macacas received 6?cm (3?mm diameter) common abdominal artery common iliac interposition with ePTFE grafts. Nontraumatic suture was used on the proximal anastomotic stomas and titanium stapler on the distal ends. After resected for four weeks, all anastomotic stomas checked with light microscopy and electroscopy. Results Complete intima coverage was also found in titanium stapler group; and much thrombus coverage was also found in suture group. Conclusions Only a slight injury occurs in titanium stapler for artery anastomosis but important role is plaped in preventing early thrombosis formation and anaphase intimal hyperplasia of the anastomotic stomas.