| 内质网应激、肠黏膜屏障与炎症性肠病 |
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| 引用本文： | 郝献华,龚剑峰. 内质网应激、肠黏膜屏障与炎症性肠病[J]. 肠外与肠内营养, 2011, 18(1): 50-53 |
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| 作者姓名： | 郝献华 龚剑峰 |
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| 作者单位： | 南京大学医学院临床学院(南京军区南京总医院)解放军普通外科研究所,江苏南京,210002 |
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| 摘 要： | 未折叠蛋白在内质网中大量蓄积引起的内质网应激(ERS),可能是引起炎症性肠病(IBD)的关键机制,受到人们广泛的关注.肠上皮细胞分泌功能高,极易受ERS的影响.上皮细胞未折叠蛋白反应(UPR)途径的自身缺陷或细胞内错误折叠蛋白产生过多,都可引起ERS,导致肠黏膜屏障损伤和肠黏膜炎症.而肠腔共生菌群和黏膜炎性因子等,都可...
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| 关 键 词： | 炎症性肠病 内质网应激 未折叠蛋白反应 |
Endoplasnic reticulum stress zntestinal mucosal barrier and inflammatory bowel disease |
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| HAO Xian-hua,GONG Jian-feng. Endoplasnic reticulum stress zntestinal mucosal barrier and inflammatory bowel disease[J]. Parenteral & Enteral Nutrition, 2011, 18(1): 50-53 |
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| Authors: | HAO Xian-hua GONG Jian-feng |
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| Affiliation: | HAO Xian-hua,GONG Jian-feng reviewing,LI Ning checking(Research Institute of General Surgery,Clinical School of Medical College of Nanjing University /Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China) |
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| Abstract: | The endoplasmic reticulum(ER) responds to the accumulation of unfolded proteins in its lumen(ER stress) by activating intracellular signal transduction pathways-cumulatively called the unfolded protein response(UPR),which has recently been implicated as a novel mechanism that may lead to inflammatory bowel disease(IBD).Impairment of proper ER stress resolution in intestinal epithelium can primarily lead to inflammation.Failing to manage ER stress may not only be a primary originator of intestinal inflammati... |
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| Keywords: | Inflammatory bowel disease Endoplasmic reticulum stress Unfolded protein response |
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