Protein phosphatase 5 as a negative key regulator of Raf-1 activation |
| |
Authors: | Bukhtiar H. Shah Kevin J. Catt |
| |
Affiliation: | aSection on Hormonal Regulation, NICHD, National Institutes of Health, Bethesda, MD 20892, USA |
| |
Abstract: | Growth factors such as the epidermal growth factor cause sequential activation of receptor tyrosine kinases, adaptor molecules and the Raf-MEK-ERK pathway. The kinetics and intensity of these signals are dependent on the balance between phosphorylation and dephosphorylation of these molecules by numerous kinases and phosphatases, respectively. Recently, protein phosphatase 5 has been characterized as a key dephosphorylation regulator of Raf-1 activation in growth factor-mediated signaling, leading to attenuation of the MEK-ERK cascade. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|