| 心肌梗死患者及同胞载脂蛋白(a)基因5’端多态性的研究 |
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| 引用本文： | 郭 然,白小涓,王 勃,赵 玫,陈 燕. 心肌梗死患者及同胞载脂蛋白(a)基因5’端多态性的研究[J]. 大连医科大学学报, 2007, 29(6): 528-531 |
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| 作者姓名： | 郭 然 白小涓 王 勃 赵 玫 陈 燕 |
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| 作者单位： | 1. 大连医科大学,第一临床学院,心内科,辽宁,大连,116011
2. 中国医科大学,附属第一医院,循环内科,辽宁,沈阳,110001 |
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| 摘 要： | [目的]研究载脂蛋白(a)基因5'端启动子五核苷酸重复序列(PNR)数目与Lp(a)水平及心肌梗死(MI)的关系.[方法]对59例男性MI患者、78例同性别同胞和60例年龄、性别相匹配的健康人行临床检查,并从分子遗传学角度行apo(a)基因5'端PNR数目的检测,研究其与Lp(a)水平及心肌梗死发病的关系.[结果]MI组Lp(a)(602±583)mg/L,同胞组(423±365)mg/L,均显著高于对照组(156±144)mg/L(P＜0.01),且MI组更高于同胞组(P＜0.01).载脂蛋白(a)基因5'端PNR扩增产物中观察到五种等位基因,MI组和同胞组PNR-8发生率最高(63.6%和34.6%),对照组PNR-10最常见(40.8%).PNR8/8基因型MI的患病危险为非8/8基因型者的8.09倍(P＜0.01),PNR9/8基因型MI的患病危险为非9/8基因型者的30.20倍(P＜0.01).MI组和同胞组PNR平均-8、8.5基因型Lp(a)水平显著高于对照组(P＜0.01).[结论]apo(a)基因5'端PNR数目与Lp(a)水平及MI发病密切相关,PNR-8/8基因型可能是MI的一个预测因子.
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| 关 键 词： | 心肌梗死 同胞 载脂蛋白(a) 脂蛋白(a) |
| 文章编号： | 1671-7295（2007）06-0528-04 |
| 收稿时间： | 2007-06-28 |
| 修稿时间： | 2007-11-10 |
Pentanucleotide repeat polymorphism in 5'''' control region of apo (a) gene among myocardial infarction patients and their siblings |
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| GUO Ran,BAI Xiao-juan,WANG Bo,ZHAO Mei and CHEN Yan. Pentanucleotide repeat polymorphism in 5'''' control region of apo (a) gene among myocardial infarction patients and their siblings[J]. Journal of Dalian Medical University, 2007, 29(6): 528-531 |
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| Authors: | GUO Ran BAI Xiao-juan WANG Bo ZHAO Mei CHEN Yan |
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| Affiliation: | Department of Cardiology,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China;;Department of Cardiology,the First Affiliated Hospital of China Medical University , Shenyang 110001,China;Department of Cardiology,the First Affiliated Hospital of China Medical University , Shenyang 110001,China;Department of Cardiology,the First Affiliated Hospital of China Medical University , Shenyang 110001,China;Department of Cardiology,the First Affiliated Hospital of China Medical University , Shenyang 110001,China |
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| Abstract: | |
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| Keywords: | myocardial infarction siblings apolipoprotein(a) lipoprotein(a) |
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