Preoperative MR imaging for ESMO-ESGO-ESTRO classification of endometrial cancer |
| |
Authors: | P. Lavaud B. Fedida G. Canlorbe S. Bendifallah E. Darai I. Thomassin-Naggara |
| |
Affiliation: | 1. Service d’imagerie, institut universitaire de cancérologie, Sorbonne université, UPMC université Paris 06, hôpital Tenon, Assistance publique–Hôpitaux de Paris (AP–HP), 4, rue de la Chine, 75020 Paris, France;2. Service de gynécologie et obstetrique, Sorbonne université, UPMC université Paris 06, institut universitaire de cancérologie, hôpital Tenon, Assistance publique–Hôpitaux de Paris (AP–HP), 4, rue de la Chine, 75020 Paris, France;3. Inserm–UMR S938, faculté de médecine Pierre et Marie Curie, Site Saint-Antoine, 27, rue Chaligny, 75571 Paris cedex 12, France |
| |
Abstract: | ObjectiveTo retrospectively investigate whether magnetic resonance imaging (MRI) findings could contribute to predict histologic type, tumor grade and lymphovascular space invasion (LVSI) to improve preoperative assessment of endometrial cancer using the European Society for Medical Oncology (ESMO) European Society for Radiotherapy & Oncology (ESTRO) and European Society of Gynecological Oncology (ESGO) classification.MethodsBetween January 2008 and August 2014, 104 women (mean age, 65 ± 11 [SD] years; range, 32–84 years) with International Federation of Gynecology and Obstetrics (FIGO) stage I endometrial cancer underwent preoperative MRI of the pelvis. Two independent readers evaluated tumor heterogeneity and measured tumor size on T2-weighted, diffusion-weighted and T1-weighted images obtained after gadolinium chelate administration at 2 minutes. The apparent diffusion coefficient (ADC) was generated from pixel ADC from the whole tumor volume.ResultsA short axis > 24 mm on MRI was associated with histopathologic type 2, grade 3 tumor and presence of LVSI (P < 0.01). There were no significant differences in minimum, mean and maximum ADC between presence/absence of LVSI. In 9.1% women (9/99), the accuracy of the ESMO-ESGO-ESTRO classification with the inclusion of the MRI short-axis criterion was higher than that of the conventional ESMO classification to predict high-risk recurrence endometrial cancer (P = 0.02).ConclusionTumor size reflects histologic type, tumor grade and LVSI in endometrial cancer. FIGO stage 1 endometrial cancer > 24 mm should be classified preoperatively in the high-intermediate or high-risk recurrence risk groups. |
| |
Keywords: | Endometrial cancer Tumor size Magnetic resonance imaging (MRI) Tumor grade Lymphovascular space invasion |
本文献已被 ScienceDirect 等数据库收录! |
|