| 分娩发动前后胎盘中白细胞抗原G1 mRNA和NK细胞的变化 |
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| 引用本文： | 何明,邹丽,朱剑文.分娩发动前后胎盘中白细胞抗原G1 mRNA和NK细胞的变化[J].现代妇产科进展,2007,16(3):197-198. |
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| 作者姓名： | 何明 邹丽 朱剑文 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院妇产科,武汉,430022 |
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| 摘 要： | 目的:检测胎盘及蜕膜组织中白细胞抗原G1(HLA-G1)mRNA和NK细胞在足月妊娠分娩发动前后的变化,探讨其在分娩发动中的作用。方法:通过RT-PCR法检测足月妊娠晚期未临产组(剖宫产组)和临产组胎盘组织中HLA-G1 mRNA的表达,并用免疫组织化学方法测定蜕膜中NK细胞的数量。结果:与未临产组相比临产组胎盘组织中HLA-G1 mRNA表达明显下降,差异有统计学意义(P<0.05);临产组蜕膜中NK细胞数量明显多于未临产组(P<0.05)。结论:分娩发动时胎盘组织表达HLA-G1mRNA下降,蜕膜组织中NK细胞数量明显增多,推测HLA-G1表达下降激活NK细胞可能参与了分娩发动。
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| 关 键 词： | HLA抗原 杀伤细胞 天然 分娩发作 妊娠 |
| 文章编号： | 1004-7379(2007)03-0197-02 |
| 修稿时间： | 2006年10月21 |
Changes of HLA-G1 mRNA expression and NK cell in placenta during labor onset |
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| He Ming,Zou Li,Zhu Jianwen.Changes of HLA-G1 mRNA expression and NK cell in placenta during labor onset[J].Current Advances In Obstetrics and Gynecology,2007,16(3):197-198. |
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| Authors: | He Ming Zou Li Zhu Jianwen |
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| Abstract: | Objective:To investigate the changes of HLA-G1 mRNA expression and NK cell number in placenta during labor onset.Method:RT-PCR was used to determine HLA-G1 mRNA expression in placenta of both in no-labor(cesarean section group)and labor group.Immunochemistry was used to identify the NK cell in deciduas in both groups.Result:HLA-G1mRNA remarkably decreased while NK cell notably increased in in labor group compared with cesarean section group(P<0.05).Conclusion:Activating NK cell by decreased HLA-G1 may trigger labor onset. |
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| Keywords: | HLA antigens Killer cell nature Labor onset Pregnancy |
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