The implications of fetal programming of glomerular number and renal function |
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Authors: | J?rg D?tsch Christian Plank Kerstin Amann Julie Ingelfinger |
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Institution: | (1) Department of Pediatric Nephrology, University of Erlangen–Nuremberg, Loschgestrasse 15, 91054 Erlangen, Germany;(2) Department of Nephropathology, University of Erlangen–Nuremberg, Erlangen, Germany;(3) Harvard Medical School, Boston, MA, USA |
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Abstract: | Large epidemiological studies suggest a clear relation between low birth weight and adverse renal outcomes evident as early
as during childhood. Such adverse outcomes may include glomerular disease, hypertension, and renal failure. Data from autopsy
material and from experimental models suggest that reduction in nephron number via diminished nephrogenesis may be a major
mechanism, and factors that lead to this reduction are incompletely elucidated. Other mechanisms appear to be renal (e.g.,
via the intrarenal renin–angiotensin–aldosterone system) and nonrenal (e.g. changes in endothelial function). It also appears
likely that the outcomes of fetal programming may be influenced postnatally, for example, by the amount of nutrients given
at critical times. |
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Keywords: | Fetal Epigenetics Pediatrics |
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