MAGE-A antigens in lesions of the oral mucosa |
| |
Authors: | Eva Krauss Stephan Rauthe Stefan Gattenlöhner Tobias Reuther Michael Kochel Ulrike Kriegebaum Alexander C Kübler Urs D A Müller-Richter |
| |
Institution: | 1.Department of Oral and Maxillofacial Plastic Surgery,University Hospital Würzburg,Würzburg,Germany;2.Institute of Pathology,University Hospital Würzburg,Würzburg,Germany |
| |
Abstract: | Oral squamous cell carcinoma develops continuously out of predamaged oral mucosa. For the physician and pathologist, difficulties
arise in distinguishing precancerous from cancerous lesions. MAGE-A antigens are tumor antigens that are found solely in malignant
transformed cells. These antigens might be useful in distinguishing precancerous from cancerous lesions. The aim of this study
was to verify this assumption by comparing MAGE-A expression in benign, precancerous, and cancerous lesions of the oral mucosa.
Retrospectively, biopsies of different oral lesions were randomly selected. The lesions that were included are 64 benign oral
lesions (25 traumatic lesions (oral ulcers), 13 dental follicles, and 26 epulis), 26 oral lichen planus, 123 epithelial precursor
lesions (32 epithelial hyperplasia found in leukoplakias, 24 epithelial dysplasia found in leukoplakias, 26 erythroplasia
with oral epithelial dysplasia, and 41 carcinomas in situ in erythroleukoplakias). The lesions were immunohistochemically
stained with the poly-MAGE-A antibody 57B, and the results were compared. Biopsies of oral lichen planus, oral ulcers, dental
follicles, epulis, and leukoplakia without dysplasia showed no positive staining for MAGE-A antigens. Leukoplakia with dysplasia,
dysplasia, and carcinomata in situ displayed positive staining in 33%, 65%, and 56% of the cases, respectively. MAGE-A antigens
were not detectable via immunohistochemistry in benign lesions of the oral mucosa. The staining rate of dysplastic precancerous
lesions or malignant lesions ranged from 33% to 65%. The MAGE-A antigens might facilitate better differentiation between precancerous
and cancerous lesions of the oral mucosa. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|