力骨胶囊防治大鼠实验性骨质疏松症的药效学

目的研究力骨胶囊预防和治疗维甲酸致大鼠骨质疏松症的药效学。方法采用维甲酸致大鼠实验性骨质疏松模型 ,随机分组给药 ,检测实验鼠股骨密度、断裂载荷、湿重、干重等物理指标及相关生化指标。结果力骨胶囊能明显提高模型大鼠的股骨密度和断裂载荷 ,显著增加模型大鼠血清Ca、P、Mg水平 ,降低模型大鼠血清ALP水平及羟脯氨酸与肌酐比值 ,并增加模型大鼠的股骨湿重、干重、灰重、体积、长度、直径等。结论力骨胶囊可有效地预防和治疗维甲酸诱导的大鼠实验性骨质疏松

Studies on the effects of the ligu capsules on preventing and treating the osteoporosis

Objective To study the effective of ligu capsules (traditional Chinese medicine) in rats with osteoporosis induced by retinoic acid.Method Osteoporosis model was established through treating with retinoic acid. Bone mineral density, bone bending strength, the level of Ca、P、Mg、Cu、Zn in serum and bone weight、bone length、bone diameter were measured. Results Femur bone mineral density, bone bending strength, the level of Ca、P、Mg in serum in ligu capsules groups were significantly increased than those in model group.Compared with model group, level of serum-ALP and HOP/Cre were decreased,while femur weight、bone length、bone diameter were increased in ligu capsules groups.Conclusions The data indicated that ligu capsules could prevent and treat osteoporosis in model rats induced by retinoic acid.