曲安奈德治疗霰粒肿的疗效及安全性调查

目的评价曲安奈德注射治疗霰粒肿的疗效和安全性。方法收集门诊初发和复发性霰粒肿患者97例(102只眼),行病变内曲安奈德注射(0.1～0.2ml,40mg/ml)。治疗后病变体积减小80%以上且无再次增大或复发为有效。治疗患者者再次注射,再次注射后无效者可选择更多次注射或手术切除。结果多数患者一次注射后有效(66只眼,64.7%)或者二次注射有效(16只眼,15.7%),平均治疗有效时间为2.7周。初发和复发性霰粒肿对于曲安奈德治疗的临床反应相似,在注射次数、体积减小和治疗有效时间上无差异。性别、年龄和病程和治疗反应无相关性。术前术后眼压和视力保持稳定。无相关并发症发生。结论初发和复发性霰粒肿曲行安奈德注射安全有效,多数病例1～2次注射即有效果,对于2～3次注射无效患者可行手术切除。

The investigation to effect and safety of triamcinolone acetonide injection for primary and recurrent chalazia

Objective To evaluate the efficacy and safety of intralesional triamcinolone acetonide (TA) injection in primary and recurrent chalazia.Methods One ninety seven patients with primary or recurrent chalazia (102 cases) treated at the out-patient clinic from July, 2005 to December, 2005. Patients received an intralesional injection of 0.1 to 0.2 ml TA (40 mg/ml). Success was defined as at least an 80% decrease in size without recurrence. If the decrease of lesion size was minimal (<50%), further injections were given as needed. Patients who declined injection or who did not respond to 2 to 3 injections were referred for surgical excision. Results Most of the patients received 1 injection (66 patients,64.7%) or 2 injections (16 patients; 15.7%) with resolution of the lesion, with an average time to resolution of 2.7 weeks. Clinical response to TA injection was similar in cases of new and recurrent chalazia, and no difference was found in the number of injections, the percentage decrease, and the time to resolution. No correlation was found between gender, age, duration of chalazion, number of injections, the percentage decrease and time to resolution. Intraocular pressure and visual acuity remained stable after treatment. No complications, such as subcutaneous fat atrophy, or skin depigmentation changes, were noted with steroids injections.Conclusion Intralesional TA injection in primary and recurrent chalazia is effective in achieving lesion regression. Most cases resolve with an average of 1 to 2 injections. Chalazia that fail to respond to 2 or 3 injections could benefit from surgical excision.