单囊型成釉细胞瘤临床病理及凝集素免疫组织化学研究

目的 研究单囊型成釉细胞瘤的临床病理及凝集素免疫组织化学特点，探索有助于诊断和临别诊断的组织学标记物。方法 对４０例单囊型成釉细胞瘤行ＨＥ染色及组织学观察；并对其中的２５例行荆豆凝集素（ＵＥＡ－１）、兀鹰血凝集素（ＢＳＡ－１）免疫组织化学染色。结果 ４０例 单囊型成釉细胞瘤，组织学上可分为３个亚型：第一型５例（１２．５％），第二型２０例（５０．０％），第三型１５例（３７．５％）；ＵＥＡ－１、ＢＳＡ

A study of clinicopathology and lectin immunohistochemistry in unicystic ameloblastoma

OBJECTIVE: To investigate clinicopathological characteristics of unicystic ameloblastoma and histological markers for differential diagnosis with odontogenic cyst. METHODS: HE staining and histopathological observation, and lectin UEA-1, BSA-1 immunohistochemistry staining. RESULTS: 40 cases of unicystic ameloblastoma were divided histologically into 3 groups. In odontogenic cysts, most of epithelial lining showed positive binding with UEA-1 and BSA-1, whereas negative reactions were obtained for these two lectins in the epithelial components of unicystic ameloblastoma and solid or multicystic ameloblastoma, except for limited UEA-1 or BSA-1 binding to markedly keratinized tumor cells in several cases of ameloblastomas. CONCLUSION: The unicystic ameloblastoma is a distinct entity which has characteristic clinicopathology. The lectin staining for UEA-1 and BSA-1 is a useful histological aid to differential diagnosis between unicystic ameloblastoma and odontogenic cyst.