液基细胞学与HPV检测对宫颈癌筛查的对比

 目的　评价液基细胞学 (ThinPrep)和肿瘤相关人乳头瘤病毒 (HPV)检测对宫颈癌的筛查能力。方法　随机选择 35～ 4 5岁妇女同时做ThinPrep ,自取材HPV检测 ,液基标本HPV检测和阴道镜活检。以阴道镜活检诊断为标准 ,比较 3种检查对宫颈鳞状上皮内高度病变 (HSIL ,CIN2 / 3)和鳞状细胞癌 (SCC)筛查的准确性。结果　 1997例受检者中阴道镜活检诊断HSIL(CIN2 / 3) 74例 ,SCC12例。ThinPrep与自取材和液基标本HPV检测的敏感性无显著差异 (P >0 .0 5 )而特异性显著高于后两者 (P <0 .0 1)。 3种检查有较好的一致性。结论　ThinPrep细胞学和HPV检测是筛查宫颈癌可选用的方法

Lquid-based cytologic screening compared with HPV testing to detect cervical cancer

Objective To evaluate the capacity of Thin Prep and HPV in testing of vaginal samples.Methods Women were instructed to collect a vaginal sample for HPV testing, then exfoliative cervical samples and subsequent colposcopic biopsies were taken on all subjects.Cervical samples were collected into a liquid buffer and utilized for both cytologic screening using ThinPrep and HPV testing of residual liquid|based cytologic samples. All the tests were performed in an independent and blinded fashion.Results HSIL(CIN2/3) and SCC were identified in 86(4.3%) of 1997 women. There were nosignificant difference for the sensitivity between ThinPrep cytology and HPV testing of either self|collected vaginal samples or residual liquid|based cytologic samples ( P >0.05). The specificity of ThinPrep cytology was significant greater than the specificity of HPV testing of either self|collected vaginal samples or residual liquid|based cytologic samples( P <0.01).There were good concordance among these three groups.Conclusion ThinPrep cytology and HPV testing are the good methods for screening cervical carcinoma.