Catalog of 238 variations among six human genes encoding solute carriers (hSLCs) in the Japanese population |
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| Authors: | S Saito A Iida A Sekine C Ogawa S Kawauchi S Higuchi Y Nakamura |
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| Institution: | (1) Laboratory for Genotyping, SNP Research Center, Yokohama Institute, Institute of Physical and Chemical Research, Yokohama, Japan, JP;(2) Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. yusuke@ims.u-tokyo.ac.jp, JP |
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| Abstract: | We screened DNAs of 48 Japanese individuals for single-nucleotide polymorphisms (SNPs) in six genes encoding proteins of
the solute carrier (SLC) family by direct sequencing of their entire genomic regions except for repetitive-sequence elements.
This approach identified 213 SNPs and 25 insertion/deletion polymorphisms among the six genes. On average, we identified 1
SNP in every 509 nucleotides. Of the 213 SNPs, 14 were identified in the SLC10A1 gene, 51 in SLC15A1, 29 in SLC22A1, 27 in SLC22A2, 54 in SLC22A4, and 38 in SLC22A5. Eight were located in 5′ flanking regions, 172 in introns, 25 in exons, and 8 in 3′ flanking regions. These variants should
contribute to investigations of possible correlations between genotypes and phenotypes as regards disease susceptibilities
or responsiveness to drug therapy.
Received: July 24, 2002 / Accepted: July 25, 2002
Correspondence to:Y. Nakamura |
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| Keywords: | SNP SLC10A1 SLC15A1 SLC22A1 SLC22A2 SLC22A4 SLC22A5 |
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