| 延胡索中9种生物碱对醌还原酶诱导活性研究 |
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| 引用本文： | 施菁,李元圆,崔勤敏,陈婷,上官盈盈.延胡索中9种生物碱对醌还原酶诱导活性研究[J].中国现代应用药学,2011,28(4):290-294. |
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| 作者姓名： | 施菁 李元圆 崔勤敏 陈婷 上官盈盈 |
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| 作者单位： | 浙江医学高等专科学校药学系，杭州 310053;浙江医学高等专科学校药学系，杭州 310053;浙江医学高等专科学校药学系，杭州 310053;浙江医学高等专科学校药学系，杭州 310053;浙江医学高等专科学校药学系，杭州 310053 |
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| 基金项目： | 浙江省科技厅分析测试基金(2008F70017) |
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| 摘 要： | 目的 对延胡索的生物碱类成分及其醌还原酶(QR)诱导活性进行系统研究.方法 运用色谱学和波谱学方法分离鉴定了9个化合物的结构,并对分离得到的化合物单体进行QR诱导活性测定.结果 从该植物中分得9个化舍物,分别鉴定为d-紫堇碱(Ⅰ)、去氢海罂粟碱(Ⅱ)、四氢巴马汀(Ⅲ)、原阿片碱(Ⅳ)、α-别隐品碱(Ⅴ)、四氢非洲防己碱...
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| 关 键 词： | 延胡索 生物碱 醌还原酶 |
| 收稿时间： | 2010/7/19 0:00:00 |
Study on Nine Alkaloids from Corydalis Rhizoma with Quinone Reductase Inducing Activities |
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| SHI Jing,LI Yuanyuan,CUI Qinmin,CHEN Ting and SHANGGUAN Yingying.Study on Nine Alkaloids from Corydalis Rhizoma with Quinone Reductase Inducing Activities[J].The Chinese Journal of Modern Applied Pharmacy,2011,28(4):290-294. |
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| Authors: | SHI Jing LI Yuanyuan CUI Qinmin CHEN Ting and SHANGGUAN Yingying |
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| Institution: | Department of Pharmacy, Zhejiang Medical College, Hangzhou 310053, China;Department of Pharmacy, Zhejiang Medical College, Hangzhou 310053, China;Department of Pharmacy, Zhejiang Medical College, Hangzhou 310053, China;Department of Pharmacy, Zhejiang Medical College, Hangzhou 310053, China;Department of Pharmacy, Zhejiang Medical College, Hangzhou 310053, China |
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| Abstract: | OBJECTIVE To study the chemical constituents from Corydalis Rhizoma and their quinone reductase（QR） inducing activties in vitro.METHODS Chromatographic and spectroscopic methods were used to isolate and identify the alkaloids from the ethanol extraction of Corydalis Rhizoma.QR induction assay was employed to investigate the QR inducing activities of the isolated alkaloids.RESULTS Nine compounds were isolated and identified as d-corydaline（Ⅰ）,dehydroglaucine（Ⅱ）,tetrahydropalmatin（Ⅲ）,protopine（Ⅳ）,α-allocryptopine（Ⅴ）,tetrahydrocolumbamine（Ⅵ）,dehydrocorydaline（Ⅶ）,berberine（Ⅷ）,palmatine（Ⅸ）.Among these alkaloids,d-corydaline（Ⅰ） and tetrahydrocolumbamine（Ⅵ） possessed moderate QR inducing activities in vitro.CONCLUSION The QR inducing activities of alkaloids from Corydalis Rhizoma were investigated for the first time,and the results generally show a positive significance. |
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| Keywords: | Corydalis Rhizoma alkaloids quinone reductase |
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