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| 丹参川芎嗪注射液对低糖低氧/复供损伤大鼠皮层神经元的保护作用 | |
| 引用本文： | 凌大林,丁成赟,王胜军. 丹参川芎嗪注射液对低糖低氧/复供损伤大鼠皮层神经元的保护作用[J]. 江苏大学学报(医学版), 2011, 21(1): 9-14,1 |
| 作者姓名： | 凌大林 丁成赟 王胜军 |
| 作者单位： | 1. 江苏大学基础医学与医学技术学院免疫学系,江苏,镇江,212013;首都医科大学附属北京天坛医院检验科,北京100050 2. 首都医科大学附属北京天坛医院神经内科,北京,100050 3. 江苏大学基础医学与医学技术学院免疫学系,江苏,镇江,212013 |
| 基金项目： | 江苏省教育厅自然科学基金资助项目,江苏省卫生厅医学科研基金资助项目,江苏大学"拔尖人才工程"和高级人才基金资助项目 |
| 摘 要： | 目的:通过建立新生大鼠的原代皮层神经元低糖低氧/复供损伤模型,探讨丹参川芎嗪注射液对缺血缺氧条件下神经细胞的保护作用.方法:选用新生大鼠的皮层神经元为研究对象,利用Na2S2O4与细胞共孵育造成神经细胞低糖低氧损伤,观察皮层神经元一般形态学及凋亡相关形态学的改变、检测神经元存活率、神经细胞外液乳酸脱氢酶(LDH)活性、... |
| 关 键 词： | 丹参川芎嗪注射液 神经细胞 氧自由基 线粒体膜电位 |
Salvia ligustrazine protects rat cortical neuron at low carbohydrates, hypoxia and reperfusion injury |
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| LING Da-lin,DING Cheng-yun,WANG Sheng-jun. Salvia ligustrazine protects rat cortical neuron at low carbohydrates, hypoxia and reperfusion injury[J]. Journal of Jiangsu University Medicine Edition, 2011, 21(1): 9-14,1 | |
| Authors: | LING Da-lin DING Cheng-yun WANG Sheng-jun |
| Affiliation: | LING Da-lin1,2,DING Cheng-yun3,WANG Sheng-jun1(1.Department of Immunology,School of Medical Science and Laboratory Medicine,Jiangsu University,Zhenjiang Jiangsu 212013,2.Clinical Laboratory,3.Department of Neurology,Beijing Tiantan Hospital Affiliated to Capital Medical University,Beijing 100050,China) |
| Abstract: | Objective: Through to establish the model of neonatal rat primary cortical neurons of oxygen and glucose deprivation/recovery(OGD/R)for the damage to explore salvia ligustrazine on nerve cells under hypoxia ischemia.Methods: Selected cortical neurons of neonatal rats to study,use of sodium dithionite(Na2S2O4) were incubated with the cells caused by oxygen and glucose deprivation neuronal injury,observe the general morphology of cortical neurons and morphological changes of apoptosis-related,detection of neu... |
| Keywords: | salvia ligustrazine nerve cells oxygen free radicals mitochondrial membrane point |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |