乌司他丁联合血必净治疗急性呼吸窘迫综合征临床研究

目的 探讨联合应用乌司他丁和血必净注射液治疗急性呼吸窘迫综合征(ARDS)的临床疗效及安全性.方法 将符合诊断标准的96例患者随机分为治疗组A(乌司他丁和血必净)、治疗组B(血必净)及对照组各32例,观察治疗前后患者呼吸频率、血氧饱和度、氧合指数等指标,抽取外周血测定血清肿瘤坏死因子α、白介素6的浓度,并记录住重症监护...

Clinical research of Ulinastatin combining with Xuebijing injection on treatment of acute respiratory distress syndrome

Objective To investigate the clinical effects and safety of Ulinastatin combining with Xuebijing injection on treatment of acute respiratory distress syndrome (ARDS). Methods 96 ARDS patients were randomly divided into group A (treated with Ulinastatin and Xuebijing injection), group B (treated with Xuebijing injection) and control group, 32 cases were in each group. Respiratory rate, oxygen saturation and oxygenation index of the patients were observed before and after treatment, serum tumor necrosis factor-α and interleukin-6 were detected,and time in intensive care unit, total length of stay and mortality were recorded. Results Ulinastatin combining with Xuebijing injection could obviously improve respiratory function testing index of ARDS patients, decrease tumor necrosis factor-α and interleukin-6 levels,shorten the length of stay,and reduce mortality. The results were better than that in control group (P ＜ 0. 05). Conclusions Ulinastatin combining with Xuebijing injection can improve the clinical symptoms and curative effect of ARDS patients, reduce significantly mortality.