CD40在T细胞介导的免疫反应中的作用

CD40-CD40L共刺激信号通路的激活在T细胞介导的免疫应答反应中具有举足轻重的作用.表达于抗原递呈细胞(APC)表面的CD40通过与表达于T细胞表面的CD40L结合而发生激活,在参与诱导机体抗感染所必需的早期炎症反应的同时,还介导了自身免疫性病理损伤的发生.同时,有证据表明CD40分子也表达于T细胞,并可作为共刺激...

The role of CD40 in T cell-mediated immune response

The activation of CD40-CD40L costimulatory signal channel plays a necessary role in T cellmediated immune response. Activation of CD40 on antigen presenting cells by CD40L which expressed on Tlymphocytes, while contributing to the pro-in? ammatory response necessary for eradication of infection, accounts for the pathology in autoimmunity. Meanwhile, there is evidence that CD40 is also expressed on T-lymphocytes and can act as a costimulatory molecule. Further dissection of the exact nature and role of CD40 in T cell activation could lead the way to novel therapeutics for diseases which include organ-graft refection, autoimmune diseases,tumor, and inflammation.