| 保罗样激酶1和p53在食管鳞癌中的表达及临床意义 |
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| 引用本文： | 殷力佳,陈德玉,胡琴. 保罗样激酶1和p53在食管鳞癌中的表达及临床意义[J]. 江苏大学学报(医学版), 2011, 21(1): 58-61,93 |
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| 作者姓名： | 殷力佳 陈德玉 胡琴 |
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| 作者单位： | 江苏大学附属医院放疗科,江苏,镇江,212001 |
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| 摘 要： | 目的:探讨保罗样激酶1(PLK1)和p53蛋白在食管鳞状细胞癌(ESCC)组织中的表达及其临床意义.方法:采用免疫组织化学法分别检测87例食管鳞状细胞癌、53例癌旁组织及42例正常食管黏膜组织中PLK1及p53蛋白的表达,并分析两者的表达水平与临床病理因素的关系.采用χ2检验进行统计学分析.结果:PLK1蛋白在食管鳞状...
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| 关 键 词： | 食管鳞状细胞癌 保罗样激酶1(PLK1) p53 免疫组织化学 |
Clinicopathological significance of PLK1 and p53 expression in esophageal squamous cell carcinoma |
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| YIN Li-jia,CHEN De-yu,HU Qin. Clinicopathological significance of PLK1 and p53 expression in esophageal squamous cell carcinoma[J]. Journal of Jiangsu University Medicine Edition, 2011, 21(1): 58-61,93 |
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| Authors: | YIN Li-jia CHEN De-yu HU Qin |
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| Affiliation: | YIN Li-jia,CHEN De-yu,HU Qin(Department of Radiation Oncology,the Affiliated Hospital of Jiangsu University,Zhenjiang Jiangsu 212001,China) |
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| Abstract: | Objective: To detect the expression of PLK1 and p53 proteins in esophageal squamous cell carcinoma(ESCC) and to analyze their clinicopathological significance.Methods: The expression of PLK1 and p53 proteins was detected by immunohistochemistry in 87 ESCC specimens,53 tumor-adjacent dysplastic tissue specimens and 42 normal esophageal mucosa specimens.Statistical analysis was performed using the chi-square test.Results: The positive rates of PLK1 and p53 protein expression differed significantly among ESCC,... |
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| Keywords: | esophageal squamous cell carcinoma Polo-like kinase 1(PLK1) p53 immunohistochemistry |
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