| 化疗药物所致周围神经病变的防治 |
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| 引用本文： | 朱正峰,李鑫,张明智. 化疗药物所致周围神经病变的防治[J]. 国际肿瘤学杂志, 2011, 38(2): 108-110. DOI: 10.3760/cma.j.issn.1673-422X.2011.02.009 |
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| 作者姓名： | 朱正峰 李鑫 张明智 |
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| 作者单位： | 郑州大学第一附属医院肿瘤科,450052 |
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| 摘 要： | 紫杉醇类、长春碱类、铂类、沙利度胺及新药硼替佐米等常用化疗药物常可导致周围神经病变.预防或治疗化疗药物所致周围神经病变且不影响疗效的动物实验或临床试验相继进行,钙镁灌注、谷胱甘肽、硫辛酸等的应用研究也不断进展.
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| 关 键 词： | 药物疗法 周围神经 药物毒性 化疗预防 |
Prevention and treatment for chemotherapy-induced peripheral neuropathy: a review |
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| ZHU Zheng-feng,LI Xin,ZHANG Ming-zhi. Prevention and treatment for chemotherapy-induced peripheral neuropathy: a review[J]. Journal of International Oncology, 2011, 38(2): 108-110. DOI: 10.3760/cma.j.issn.1673-422X.2011.02.009 |
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| Authors: | ZHU Zheng-feng LI Xin ZHANG Ming-zhi |
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| Abstract: | Chemotherapy- induced peripheral neuropathy (CIPN) can be caused by many commonly used chemotherapeutic agents, such as taxanes, vinca alkaloids, platinum drugs, thalidomide,and also by newer agents such as bortezomib. Both animal experiments and clinical studies are being conducted to investigate strategies for preventing CIPN or ameliorating established CIPN without affecting the antitumor efficacy of chemotherapy. Treatments using calcium and magnesium infusions,glutathione,lipoid acid are being evaluated for their clinical application. |
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| Keywords: | Drug therapy Peripheral nerves Drug toxicity Chemoprevention |
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