| 萘丁美酮中间体6-甲氧基-2-萘甲醛的合成 |
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| 引用本文： | 张立光,於学良,叶蓓.萘丁美酮中间体6-甲氧基-2-萘甲醛的合成[J].安徽医药,2011,15(2):150-151. |
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| 作者姓名： | 张立光 於学良 叶蓓 |
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| 作者单位： | 苏州卫生职业技术学院药学组,江苏,苏州,215009;苏州卫生职业技术学院护理组,江苏,苏州,215009 |
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| 摘 要： | 目的制备6-甲氧基-2-萘甲醛。方法以2-甲氧基萘为原料,经溴代、还原、甲醛化制得终产物。结果反应总收率71.5%,产物结构由1H-NMR光谱确证。结论该方法简单,后处理容易,副产物较少,适合工业化生产。
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| 关 键 词： | 6-甲氧基-2-萘甲醛 合成 萘丁美酮 |
Synthesis of 6-methoxy-2-naphthaldehyde of the intermediate body of nabumetone |
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| ZHANG Li-guang,YU Xue-liang,YE Bei.Synthesis of 6-methoxy-2-naphthaldehyde of the intermediate body of nabumetone[J].Anhui Medical and Pharmaceutical Journal,2011,15(2):150-151. |
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| Authors: | ZHANG Li-guang YU Xue-liang YE Bei |
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| Institution: | ZHANG Li-guang1,YU Xue-liang1,YE Bei2(1.Pharmaceutical Group,2.Nursing Group,Suzhou Health College of Technology,Suzhou 215009,China) |
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| Abstract: | Aim To prepare 6-methoxy-2-naphthaldehyde.Methods 6-methoxy-2-naphthaldehyde was synthesized by bromide,reduction and formaldehyde-based reaction.Results The target product was synthesized in overall yield of 71.5% and its structure was confirmed by 1H-NMR spectroscopy.Conclusions The method of preparation is much easier to perform,with simple work-up and fewer by-products.It is suitable for industrial production. |
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| Keywords: | 6-methoxy-2-naphthaldehyde synthesis nabumetone |
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