| E-cad基因甲基化与消化道肿瘤的相关性 |
| |
| 引用本文： | 李永丽,丁国瑾. E-cad基因甲基化与消化道肿瘤的相关性[J]. 国际肿瘤学杂志, 2011, 38(2): 145-147. DOI: 10.3760/cma.j.issn.1673-422X.2011.02.021 |
| |
| 作者姓名： | 李永丽 丁国瑾 |
| |
| 作者单位： | 河北医科大学附属第三医院肿瘤内科,石家庄,050051 |
| |
| 基金项目： | 河北省2010年医学科学研究重点课题计划基金 |
| |
| 摘 要： | E-cad基因启动子区CpG岛甲基化是消化道肿瘤中该基因失活的主要原因,可致E-cad表达下降或缺失,与食管癌、胃癌、肝细胞癌、胆管细胞癌、胆囊癌、胰腺癌及结直肠癌等多种消化道肿瘤的发生、发展、浸润转移和预后密切相关.E-cad基因甲基化的进一步研究将有可能指导消化道肿瘤的早期诊断、基因治疗、预防及预测肿瘤转移复发等.
|
| 关 键 词： | E-钙黏着糖蛋白类 基因 甲基化 消化道肿瘤 |
Correlation of methylation of E-cad gene with gastrointestinal cancer |
| |
| LI Yong-li,DING Guo-jin. Correlation of methylation of E-cad gene with gastrointestinal cancer[J]. Journal of International Oncology, 2011, 38(2): 145-147. DOI: 10.3760/cma.j.issn.1673-422X.2011.02.021 |
| |
| Authors: | LI Yong-li DING Guo-jin |
| |
| Abstract: | The methylation of CpG island in promoter region of E-cad gene which usually leads to inactivation of E-cad gene is closely related to the occurrence, development, invasion, metastasis and prognosis of a variety of gastrointestinal cancer, such as esophageal carcinoma, gastric carcinoma, hepatocellular carcinoma,cholangiocellular carcinoma, carcinoma of gallbladder, pancreatic carcinoma and colorectal cancer. Further study would probably guide the early diagnosis, gene therapy, prophylaxis and predicting recurrence of tumor metastasis of gastrointestinal cancer. |
| |
| Keywords: | E-cadherin Gene Methylation Gastrointestinal cancer |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《国际肿瘤学杂志》浏览原始摘要信息 |
|
点击此处可从《国际肿瘤学杂志》下载免费的PDF全文 |
|
