| 髓系来源抑制细胞促进肿瘤免疫逃逸的研究进展 |
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| 引用本文： | 杜伟娇,曹水,任秀宝.髓系来源抑制细胞促进肿瘤免疫逃逸的研究进展[J].国际免疫学杂志,2011,34(1):6-8,27. |
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| 作者姓名： | 杜伟娇 曹水 任秀宝 |
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| 作者单位： | 天津医科大学附属肿瘤医院生物治疗科,天津市肿瘤防治重点实验室,300000 |
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| 基金项目： | 国家自然科学基金资助项目,天津市高等学校科技发展基金 |
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| 摘 要： | 髓系来源抑制细胞(MDSC)是髓系来源的一群异质细胞,在荷瘤小鼠模型及肿瘤患者均发挥免疫抑制作用.肿瘤MDSC免疫逃逸作用的机制目前已取得了很多进展,这群细胞可以通过上调精氨酸酶1(ARN1),诱导一氧化氮合酶(iNOS or NOS-2)表达,增加一氧化氮(NO)、活化氧自由基(ROS)等的释放,分解肿瘤微环境中的半...
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| 关 键 词： | 髓系来源抑制细胞 免疫应答 免疫逃逸 |
Myeloid derived suppressor cells enhance tumour immune escape |
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| DU Wei-jiao,CAO Shui,REN Xiu-bao.Myeloid derived suppressor cells enhance tumour immune escape[J].International Journal of Immunology,2011,34(1):6-8,27. |
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| Authors: | DU Wei-jiao CAO Shui REN Xiu-bao |
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| Institution: | ( Key Laboratory of Cancer Prevention and Therapy of Tianjin ; Department of Cancer Biotherapy, Affiliated Tumor Hospital, Tianjin Medical University, Tianjin 300060, China) |
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| Abstract: | Myeloid derived suppressor cells (MDSC) are a group of heterogeneous myeloid cells,which play a role in immune suppression in tumour-bearing mice and cancer patients. MDSC may suppress T cells by upregulating the expression or release of arginase1 ( ARN1 ), inducible nitric oxide synthase ( iNOS or NOS-2), nitric oxide ( NO), reactive oxygen species ( ROS), and disintegrating cysteine in tunour microenvironment, downregulating L-selectin of T cell. In addition, MDSC could enhance immune escape by inducing T regulatory cells, modulating innate immune, differentiating to tumor associated macrophage (TAM), secreting Th-2 type cytokines, or promoting vascular formation of tumor. |
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| Keywords: | Myeloid derived suppressor cells Immune response Immune escape |
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