螺内酯在Ⅱ型糖尿病肾病患者治疗中的作用分析

目的探讨螺内酯在Ⅱ型糖尿病肾病患者治疗中的肾脏保护作用。方法将2011年7月-2012年7月间我院Ⅱ型糖尿病肾病患者100例随机分为两组各50例，实验组采用卡托普利降压治疗并加用螺内酯20mg/d，对照组仅使用卡托普利行降压治疗，比较治疗后两组患者糖化血红蛋白、LDL-C、血钾以及24h尿蛋白量方面的差异。结果实验组24h尿蛋白量较对照组明显改善，差异有统计学意义（P〈0.05），其余各项指标无统计学差异（P〉0.05）。结论Ⅱ型糖尿病肾病患者在卡托普利控制血压的基础上加用螺内酯治疗，可以显著降低24h尿蛋白量，起到了肾脏保护作用。

The Effect Analysis of Spironolactone in the Treatment of Type 2 Diabetic Nephropathy

Objective To analysis the effect of limited fluids resuscitation in the treatment of hemorrhagic shock. Methods 100 patients with type 2 diabetic nephropathy were divided into objective group（50 cases） and control group（50 cases）. All the patients were used the captopril. The objective group was used spironolactone additional. The difference of glycosylated hemoglobin, LDL-C, potassium and the 24h urine protein quantity between the two group were compared. Results There were more positive result in the comparison of glycosylated hemoglobin, LDL-C, potassium and the 24h urine protein quantity in the objective group. Conclusions It would get a satisfactory effect to use spironolactone in the treatment of type 2 diabetic nephropathy.