血清钙与CRP联合检查对急性胰腺炎的鉴别价值

目的探讨急性胰腺炎（AP）患者体内C反应蛋白（CRP）、血清钙水平变化及其对病情的预测价值。方法将52例AP患者分为轻症急性胰腺炎（MAP）28例及重症急性胰腺炎（SAP）24例，同时选取同期健康体检者50例为对照组，分析三组患者体内CRP以及血清钙的水平的变化。结果与对照组相比，AP组患者入院时体内CRP水平显著增高，SAP组显著高于MAP组（P〈0.05）。与正常对照组相比，AP组患者血清钙水平显著低于对照组，且SAP组显著低于MAP组（P〈0.05）。CRP鉴别SAP的灵敏性、特异性、准确性分别为85.6％、82.3％、94.5％，血清钙鉴别SAP的灵敏性、特异性、准确性分别为88.5％、83.4％、85.3％，两者鉴别诊断的灵敏性、特异性、准确性分别为89.2％、85.3％、98.6％。结论 CRP及血清钙可作为急性胰腺炎的病情鉴别指标，两者联合检测的灵敏性、特异性、准确性较高。

Value of combined test of serum calcium and CRP in the monitoring of severity of acute pancreatitis

Objective To investigate the changes of the levels of C-reactive protein（CRP） and serum calcium in patients with acute pancreatitis（AP） and the value of their changes in the monitoring of disease severity of AP. Methods 52 patients with AP were divided into two groups： severe acute pancreatitis（SAP） group（28 cases） and mild acute pancreatitis（MAP） group（24 cases） based on the patient＇s condition, and 50 healthy subjects were selected as the control group. The changes of levels of CRP and serum calcium were compared between these groups. Results At admission the CRP levels in patient with AP significantly higher than that in MAP group（P 〈0.05）. The serum calcium levels in patients with AP were significantly lower than that in the control group, and serum calcium levels in SAP group was significantly lower than that in the MAP group（P〈0.05）. The diagnostic sensitivity, specificity, accuracy of CRP for the monitoring of SAP were 85.6%, 82.3%, and 95.4, respectively ,the sensitivity, specificity and accuracy of serum calcium for SAP were 82.5%, 83.4%, 92.6%, bespectively the diagnostic sensitivity, specificity, accuracy of combined test were 89.2%, 85.3%, and 98.6% respectively. Conclusion CRP and serum calcium can be used as a monitoring indicator of disease severity of AP, and detection sensitivity, specificity, accuracy the combination is higher.