糖尿病前期患者肾功能变化的研究

目的观察糖尿病前期患者血胱抑素C（CysC）、血β2微球蛋白（β2MG）、24h尿白蛋白排泄率（UAER）、血清肌酐（Scr）、尿素氮（BUN）变化及糖代谢、炎症因子指标变化，探讨不同糖尿病前期患者肾功能特点及相关危险因素。方法160例对象分为空腹血糖受损（IFG）组、糖耐量减低（IGT）组及空腹血糖并糖耐量减低（IGR）组、正常对照组，检测CysC、β2MG、UAER、Scr、BUN、空腹血糖（FPG）、空腹胰岛素、HbA1c、hsCRP等指标，统计各组指标差异。结果各糖尿病前期组β2MG、CysC、HbA1c%、hsCRP较对照组显著升高，P〈0.05；IGT组、IGR组β2MG、CysC较IFG组显著升高，P〈0.05。IFG组HOMA-IR显著高于CON组，P〈0.05；hsCRP与FPG、2hPG、HbA1c%、CysC、β2MG呈正相关。结论糖尿病前期患者存在肾损伤，餐后血糖、炎症因子与糖尿病前期肾损伤相关。

Changes in renal function in patients with pre-diabetes research

Object To observe the blood cystatin C（CysC）, serum β2-microglobulin（β2MG）, 24-hour urinary albumin excretion rate（UAER）, serum creatinine（Scr）, blood urea nitrogen（BUN） and changes in sugar metabolism, inflammatory cytokines indicators of patients with prediabetes and to explore different prediabetic state changes in renal function in patients with the characteristics and risk factors. Method 160 cases were divided into pre-diabetes impaired fasting glucose（IFG） group, impaired glucose tolerance（IGT）, impaired fasting glucose group, impaired glucose tolerance（IGR） group and control group. We measured the levels of the CysC, β2MG, UAER, Scr, BUN, fasting plasma glucose test（FPG）, fasting insulin, HbA1c and hsCRP of all cases. Result The β2MG, CysC, HbA1c%, hsCRP of pre-diabetic groups were significantly higher than the control group, P〈0.05; the β2MG, CysC of IGT group and IGR group were significantly higher than the IFG group, P〈0.05; The HOMA-IR of IFG groupwas significantly higher than the CON group, P〈0.05; hsCRP and FPG, 2hPG, HbA1c%, CysC, β2MG were positively correlated. Conclusion The presence of kidney damage in patients with pre-diabetes, postprandial hyperglycemia, inflammatory factors associated with pre-diabetic renal injury.