| T790M在非小细胞肺癌靶向治疗中的作用 |
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| 引用本文： | 丁丁,陆舜.T790M在非小细胞肺癌靶向治疗中的作用[J].临床肿瘤学杂志,2014,19(6):560-563. |
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| 作者姓名： | 丁丁 陆舜 |
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| 作者单位： | 200030.上海 上海交通大学附属胸科医院肺部肿瘤临床医学中心 |
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| 摘 要： | T790M突变是表皮生长因子受体（EGFR）敏感突变的非小细胞肺癌患者接受靶向治疗耐药的主要机制之一。研究表明，T790M突变在靶向治疗前即存在并具有一定预测疗效和预后的作用。本文就T790M在非小细胞肺癌靶向治疗作用的最新研究进展作一综述。
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| 关 键 词： | T790M 非小细胞肺癌 表皮生长因子受体 预测 预后 |
| 收稿时间： | 2013-12-10 |
| 修稿时间： | 2014-03-30 |
The role of T790M mutation in non-small cell lung cancer of targeted therapy |
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| DING Ding,LU Shun.The role of T790M mutation in non-small cell lung cancer of targeted therapy[J].Chinese Clinical Oncology,2014,19(6):560-563. |
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| Authors: | DING Ding LU Shun |
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| Institution: | Shanghai Lung Tumor Clinical Medical Center， Chest Hospital Affiliated to Shanghai Jiaotong University， Shanghai 200030， China |
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| Abstract: | T790M mutation is one of main reasons for resistance in non-small cell lung cancer patients who received targeted therapy with sensitive epidermal growth factor receptor mutation. The pretreatment T790M mutation was reported as well as resistance T790M with predictive and prognosis function. The review mainly discusses the progression about the role of T790M mutation in the targeted therapy. |
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| Keywords: | T790M Non-small cell lung cancer（NSCLC） Epidermal growth factor receptor（EGFR） Predictive Prognosis |
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