多孔羟基磷灰石微球对药物的吸附性质

目的考察多孔羟基磷灰石微球对药物的吸附性质。方法采用溶液吸附法研究市售羟基磷灰石微球对药物的吸附性质。以氯化锶为标记物,用扫描电镜-能谱分析仪定点扫描微球内锶的分布情况,氮吸附法测定微球的比表面积和孔径。结果可与羟基磷灰石上的钙离子螯合的药物吸附量相对较高,而依靠氢键或电荷间相互作用、发生物理吸附的药物吸附量偏低,难溶性药物吸附药量普遍低于水溶性药物。市售微球孔径约为30 nm,属于介孔材料,药物多分布在微球的表层。结论阐明了羟基磷灰石微球对不同类型药物的吸附特征,为其作为药物载体提供依据。

Drug adsorption properties of porous hydroxyapatite microspheres

Objective To study the drug adsorption properties on porous hydroxyapatite microspheres (HAP-MS). Methods The absorption of various drugs on commercial HAP-MS was examined using solution absorption method. The absorption of strontium on HAP was analyzed using SEM-EDX, and the specific surface area and pore size of HAP-MS were determined with nitrogen adsorption method. Results The amount of drugs adsorbed on HAP-MS was relatively high for drugs which can chelate with calcium ion, while only small amount of drug was adsorbed for drugs which can only physically adsorb via hydrogen bonding or charge interaction. The amount of insoluble drugs adsorbed on HAP-MS was generally lower than that of water soluble drugs. The commercial HAP-MS was mesoporous material with a most probable pore size of 30nm, and the drugs adsorbed mainly distributed on the outer layer of HAP-MS. Conclusion The drug adsorption properties on HAP-MS are determined, the results may provide valuable implication for the application of HAP-MS in drug delivery.