| 注射用苦碟子对麻醉犬血流动力学影响的研究 |
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| 引用本文： | 刘彤,丁晓飞,陈光. 注射用苦碟子对麻醉犬血流动力学影响的研究[J]. 辽宁中医杂志, 2007, 34(8): 1170-1171 |
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| 作者姓名： | 刘彤 丁晓飞 陈光 |
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| 作者单位： | 1. 辽宁省药品检验所,辽宁,沈阳,110023
2. 沈阳药科大学,辽宁,沈阳,110016 |
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| 摘 要： | 目的:研究注射用苦碟子对麻醉犬心脏血流动力学的影响。方法:麻醉犬静脉给予注射用苦碟子后,测定犬心脏血流动力学参数。结果:注射用苦碟子可显著降低麻醉犬平均动脉压(MBP)、心率(HR)、左室内压(LVP)、冠脉阻力(CVR),增加犬心输出量(CO)和冠脉血流量(CBF)。结论:注射用苦碟子可能在改善心肌收缩和舒张功能,增加心肌供血供氧等环节,发挥抗心肌缺血作用。
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| 关 键 词： | 苦碟子 血流动力学 心肌缺血 冠脉流量 |
| 文章编号： | 1000-1719（2007）08-1170-02 |
| 修稿时间： | 2007-03-28 |
Effects of lxeris sonchifolia for Injection on Hemodynamics in Anesthetized Dogs |
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| LIU Tong,DING Xiao-fei,CHEN Guang. Effects of lxeris sonchifolia for Injection on Hemodynamics in Anesthetized Dogs[J]. Liaoning Journal of Traditional Chinese Medicine, 2007, 34(8): 1170-1171 |
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| Authors: | LIU Tong DING Xiao-fei CHEN Guang |
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| Affiliation: | 1. Liaoning Institute far Drug Control,Shenyang 110023 ,Liaoning,China; 2. Shenynng Pharmaceutical University ,Shenyang 110016 ,Liaoning , China |
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| Abstract: | Objective:To study the effects of Ixeris sonchifolia for Injection on hemodynamics in anesthetized dogs.Methods:The hemodynamics parameters were observed after the anesthetized dogs were treated with Ixeris sonchifolia for Injection.Results:In the dogs treated with Ixeris sonchifolia for Injection,the mean arterial pressure(MAP),heart rate(HR),left ventricular pressure(LVP)and coronary artery vascular resistance(CVR)were decreased significantly.The cardiac output(CO) and coronary artery blood flow(CBF)were also increased significantly.In addition,the myocardial oxygen consumption andutilization rate of oxygen were decreased obviously in the anesthetized dogs.Conclusion:Ixer sonchifolifolia for Injection may have protective effects on the myocardial ischemia,including decreasing oxygen consumption and increasing the myocardial blood flow. |
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| Keywords: | Ixeris sonchifolia for Injection myocardial ischemia hemodynamics coronary arterial bond flow |
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