|
|||||
|
|
| 人脑星形细胞瘤环氧化酶-2的表达及与细胞增殖凋亡的关系 | |
| 引用本文： | 檀艳丽,方川,刘书哲,杨旭,杨永斌,饶晓松,钟延丰. 人脑星形细胞瘤环氧化酶-2的表达及与细胞增殖凋亡的关系[J]. 军医进修学院学报, 2007, 28(4): 295-296 |
| 作者姓名： | 檀艳丽 方川 刘书哲 杨旭 杨永斌 饶晓松 钟延丰 |
| 作者单位： | 1. 河北大学医学实验中心,保定,071000 2. 河北大学附属医院神经外科,保定,071000 3. 北京大学首钢医院病理科,北京,100041 4. 北京大学医学部病理学系,北京,100083 |
| 基金项目： | 河北省科技厅科技攻关计划 |
| 摘 要： | 目的:检测人脑星形细胞瘤环氧化酶-2(cyclooxygenase-2, COX-2)表达,探讨COX-2与肿瘤恶性程度、细胞增殖活性及凋亡程度的关系.方法:采用免疫组化方法检测星形细胞瘤组织中COX-2及增殖细胞核抗原(proliferating cell nuclear antigen, PCNA)、Mcl-1癌基因的表达情况.结果: 68例星形细胞瘤组织COX-2的表达阳性率为61.8%,COX-2的表达强度和病理分级呈正相关(χ2=14.24, P＜0.01).COX-2与Mcl-1、PCNA蛋白表达均呈正相关性.结论:COX-2蛋白在星形细胞瘤过度表达与病理分级及细胞增殖、凋亡关密切相关. |
| 关 键 词： | 星形细胞瘤 环氧化酶-2 细胞凋亡 细胞增殖 免疫组织化学 人脑星形细胞瘤 氧化酶 蛋白表达 增殖凋亡 关系 astrocytoma human apoptosis cell proliferation relationships cyclooxygenase 细胞增殖活性 正相关性 病理分级 表达强度 表达阳性率 结果 情况 癌基因 PCNA |
| 文章编号： | 1005-1139（2007）04-0295-02 |
| 修稿时间： | 2006-09-152007-02-06 |
Expression of cyclooxygenase 2 and its relationships with cell proliferation and apoptosis in human astrocytoma |
|
| TAN Yan-li,FANG Chuan,LIU Shu-zhe,YANG Xu,YANG Yong-bing,RAO Xiao-song,ZHONG Yan-feng. Expression of cyclooxygenase 2 and its relationships with cell proliferation and apoptosis in human astrocytoma[J]. Academic Journal of Pla Postgraduate Medical School, 2007, 28(4): 295-296 | |
| Authors: | TAN Yan-li FANG Chuan LIU Shu-zhe YANG Xu YANG Yong-bing RAO Xiao-song ZHONG Yan-feng |
| Affiliation: | 1. Hebei University Health Science Center, Baoding 071000, China ; 2. Department of Neurosurgery, Affiliated Hospital of Hebei University, Hebei Baoding 071000; 3. Department of Pathology, Peking University Shougang Hospital, Beijing 100041, China; 4. Department of Pathology, Peking University Health Science Center. Beijing 100083, China |
| Abstract: | Objective:To study the expression of cyclooxynenase 2(COX-2) in human astrocytoma and the relationships of COX-2 expression level with the malignant degree,cell proliferative activity and apoptosis of the tumors.Methods:The expression of COX-2 and that of PCNA,Mcl-1 in the astrocytoma were studied with S-P immunohistochemical staining.Results:The positive expression of COX-2 in human gliomas of 68 cases was 61.8%,which was related with the histological grade of tumor.The expression of COX-2 was positively correlated with PCNA and Mcl-1(P<0.01).Conclusion:The overexpression of COX-2 in human astrocytoma may play a crucial role in pathologic grade,cell proliferation and apoptosis in human astrocytoma. |
| Keywords: | astrocytoma cyclooxynenase 2 cell proliferation cell apoptosis immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |