PD-1/PD-L1信号通路与慢性乙型肝炎

目的：程序性死亡分子-1（programmed death-1，PD-1）是近年来发现的属于B7/CD28家族的重要协同刺激分子，与其配体（programmed death -1 ligand，PD-L）结合后在调节T淋巴细胞的活化、分化及增殖功能方面起着重要作用。在慢性HBV感染不同阶段，PD-1表达水平存在差异，且与肝脏炎症程度、ALT及病毒载量等密切相关。通过不同途径阻断PD-1/PD-L1通路可以使耗竭的T淋巴细胞功能得到改善，提示可能是未来抗病毒治疗的方向之一。

PD-1/PD-L signal pathway in chronic hepatitis B

Programmed death-1（PD-1） is an important coordinated stimulus molecule belonging to the B7/CD28 family. When it combines with its ligand programmed death ligand （PD-L）,can regulate the activation,differentiation and multiplication of T lymphocytes. PD-1 expression in different stages of chronic HBV infection varies ,and is closely related to the degree of liver inflammation,ALT levels and viral loads. Through different ways to block the PD-1/PD-L1 pathway can improve the function of T lymphocytes,and it might be one of the direction for antiretroviral treatment in the future.