| 甲基强的松龙对深低温脑缺血再灌注大鼠脑组织S-100β蛋白表达的影响 |
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| 引用本文： | 章云峰,徐康康,彭卫,莫绪明. 甲基强的松龙对深低温脑缺血再灌注大鼠脑组织S-100β蛋白表达的影响[J]. 中国生化药物杂志, 2009, 30(4) |
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| 作者姓名： | 章云峰 徐康康 彭卫 莫绪明 |
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| 作者单位： | 1. 南京医科大学,附属南京儿童医院,药剂科,江苏,南京,210008
2. 南京医科大学,附属南京儿童医院,心胸外科,江苏,南京,210008 |
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| 基金项目： | 南京市医学科技发展项目基金 |
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| 摘 要： | 目的观察甲基强的松龙(MP)对深低温脑缺血再灌注大鼠脑组织S-100β蛋白表达的影响。方法将SD大鼠随机分为假手术组、模型组和MP组,应用SABC技术检测脑组织S-100β蛋白表达。结果假手术组脑组织S-100β蛋白呈基础水平表达;MP组S-100β蛋白表达量与模型组比较显著降低。结论MP可能通过抑制S-100β的过量表达,对深低温缺血再灌注脑损害发挥保护作用。
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| 关 键 词： | 甲基强的松龙 脑损害 缺血再灌注 S-100β蛋白 |
Influence of methylprednisolone on the expression of S-100 beta protein after deep hypothermia cerebral ischemia reperfusion in rats |
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| ZHANG Yun-feng,XU Kang-kang,PENG Wei,MO Xu-Ming. Influence of methylprednisolone on the expression of S-100 beta protein after deep hypothermia cerebral ischemia reperfusion in rats[J]. Chinese Journal of Biochemical Pharmaceutics, 2009, 30(4) |
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| Authors: | ZHANG Yun-feng XU Kang-kang PENG Wei MO Xu-Ming |
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| Abstract: | Purpose To observe the effect of methylprednisolone on the expression of S-100 beta protein after deep hypothermia cerebral ischemia reperfusion in rats.Methods SD rats were divided randomly into three groups: sham group,methylprednisolone group and model group.The expressions of S-100 beta protein were detected by SABC.Results The expressions of S-100 beta protein were at basal level in sham group,while were significantly lower in methylprednisolone group than that in model group.Conclusion Methylprednisolone played a protective role in rats cerebral injury after deep hypothermia cerebral ischemia reperfusion through inhibiting the excessive expression of S-100 beta protein. |
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| Keywords: | methylprednisolone cerebral injury ischemia reperfusion S-100 beta protein |
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