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Plants traditionally used in age related brain disorders--a survey of ethnobotanical literature
Authors:Adams Michael  Gmünder Francine  Hamburger Matthias
Institution:Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.
Abstract:In traditional herbal medicine, numerous plants have been used to treat age related cognitive disorders. In this review we compiled available literature from four Swiss university libraries, scientific journals and online database query's on plants and remedies used in traditional medicinal systems for such diseases. Over 150 plant species in various preparations and mixtures were found. European herbals from the 16th and 17th century alongside traditional Chinese and Indian medicinal works were the most prolific sources. The information is organised into geographic regions and when available the findings are discussed in the light of more recent scientific findings concerning their secondary metabolites and in vitro and in vivo activities relevant to dementia and Alzheimer's disease.
Keywords:ACh  acetylcholine  AChE  acetylcholinesterase  APP  amyloid precursor protein  BuChE  butyrylcholinesterase  ChAT  choline acetyltransferase  GABA  gamma aminobutyric acid  NMDA  N-methyl-d-aspartate  PKC  protein kinase C  TCM  traditional Chinese medicine
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