急性冠状动脉综合征病人VEGF与VCAM-1水平及其与斑块稳定性的研究

目的观察急性冠状动脉综合征病人血清血管内皮生长因子(VEGF)和血管细胞黏附分子-1(VCAM-1)等指标的水平,探讨两者与斑块稳定性的关系及其临床意义.方法根据临床诊断将研究对象分为急性冠状动脉综合征组(ACS组,30例)和稳定劳累性心绞痛组(SAP组,25例),另设健康对照组(30名),测定上述观测者入院血清VEGF、VCAM-1、肌酸激酶(CK)及其同工酶(CK-MB)的水平.结果 ACS组病人血清VEGF、VCAM-1、CK﹑CK-MB水平均显著高于SAP组和健康对照组.血清VEGF的水平与血清VCAM-1水平和CK-MB水平之间有相关性(r＝0.233,P＜0.05;r＝0.547,P＜0.01),与CK水平之间无相关性(r＝-0.139,P>0.05).结论急性冠状动脉综合征的早期VEGF和VCAM-1血管水平明显升高,对判定斑块稳定性具有一定价值.

Serum Level and Relationship of VEGF with Vascular Cell Adhesion Molecule-1 in Acute Coronary Syndrome

Objective To observe the serum level of vascular endothelial growth factor and vascular cell adhesion molecule-1, explore their relationship with stability of plaque and clinical significance.Methods Thirty patients of acute coronary syndrome,25 patients of stable angina pectoris and 30 controls were selected. Serum levels of vascular endothelial growth factor,vascular cell adhesion molecule-1,CK and CK-MB were detected.Results Serum levels of vascular endothelial growth factor, vascular cell adhesion molecule-1,CK and CK-MB in acute coronary syndrome group were significantly higher than those in the other two groups, there was a relationship between the level of vascular endothelial growth factor, that of vascular cell adhesion molecule-1 and that of CK-MB, and there was no relationship between the level of vascular endothelial growth factor and that of CK.Conclusion Serum levels of vascular endothelial growth factor and vascular cell adhesion molecule-1 may increase in patients of acute coronary syndrome. It will be of some value to us in assessing the stability of atherosclerotic plaque.