Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. I. Taxonomy, production, isolation and biological activity. |
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| Authors: | J S Wells J O'Sullivan C Aklonis H A Ax A A Tymiak D R Kirsch W H Trejo P Principe |
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| Institution: | Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000. |
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| Abstract: | A screen for antibiotics with activity against tetracycline-resistant microorganisms has led to the isolation of Dactylosporangium sp. (ATCC 53693), a producer of several novel tetracycline derivatives. The major fermentation products, dactylocyclines A and B, were purified and MIC values determined against tetracycline-resistant and tetracycline-sensitive Gram-positive bacteria. The dactylocyclines represent the first naturally occurring tetracycline C2 amides which lack cross resistance with tetracycline. |
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