银杏叶片对血管性痴呆患者自由基及血液流变学的影响

目的：探求银杏叶片对VD患者自由基的清除作用及对血液流变学的影响。方法：选择60例VD患者，其中男34例，女26例，年龄56～81岁，病程2个月～3年，另选健康老人120例，其中空白对照组60例，健康组60例。观察治疗前后血清超氧化物歧化酶（SOD）、过氧化脂质（LPO）、丙乙醛（MDA）、谷胱甘肽氧化物酶（GSH-PX）活性变化及血液流变学指标。结果：治疗后SOD、GSH-PX升高，MDA、LPO降低（P〈0．05）。治疗后血液流变学各项指标均有明显改善（P〈0．05，P〈0.01）。结论：银杏叶片有抗MDA、LPO等自由基损伤和激活SOD、GSH-PX等抗脂质过氧化作用，并且可明显降低TC、TG、LDLC，升高HDL，改善血液流变学异常指标。

Effect of Ginkgo Leaf Tablet on Free Radical and Hemorheology of Vascular Dementia Patients

Objective:To study the effect of ginkgo leaf on vascular dementia patients free radical and hemorheol-ogy, Method: 60 cases of vascular dementia patients were chosen. There were 34 male cases and 26 female cases, aged 56 -81 with the course of 2 months to 3 years.120 cases of healthy old men, including 60 cases in the control group and 60 cases in the health group were chosen. The activity changes of peroxide dismutase( SOD) , perxide lipid(LPO) , malondial-dehde (MDA) and glutathione peroxidase (GSH-PX) in blood serum and hemorheology markers were observed before and after the therapy. Result: After the therapy, the activity of SOD and GSH-Px increased, and MDA and LPO declined (P< 0.05). Hemorheology markers obviously improved (P<0.05,P<0.01). Conclusion:Ginkgo leaf tablet had the effect of resisting the damage of MDA, LPO and other free radicals and activating SOD and MDA. It can dramatically decrease TC. TG, LDLC, enhance HDL, and improve the abnormal marker in Hemeoheology.