重视野生型胃肠间质瘤的诊断与治疗

胃肠间质瘤是胃肠道最常见的间叶源性肿瘤．c．kil基因或PDGFRA基因的功能获得性突变是其最重要的特征。有10％～15％的胃肠间质瘤不存在c—kit基因及PDGFRA基因的突变．称为野生型胃肠间质瘤。这一类胃肠问质瘤在分子机制及临床特征上与突变型胃肠间质瘤有湿著差异．且其本身存在高度异质性。临床医师在诊断与治疗野生型胃肠间质瘤时应当引起足够的重视。

Diagnosis and treatment of wild-type gastrointestinal stromal tumors

Gastrointestinal stromal tumors （GIST） are the most common mesenchymal tumors of the gastrointestinal tract, and are mostly characterized by c-kit or PDGFRA gain- of-function mutation. About 10%-15% of GIST do not harbor any mutations in the c-kit and PDGFRA genes and are defined as wild-type GIST. There are significant differences in molecular mechanism and clinical characteristics between wild-type GIST and mutant GIST. Wild-type GIST should be considered as a family of diseases due to their extreme heterogeneity. Clinician should pay close attention to the diagnosis and treatment of wild-type GIST.