| 胃肠间质瘤分子分型的临床实践价值 |
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| 引用本文： | 潘志忠,伍小军,姜武. 胃肠间质瘤分子分型的临床实践价值[J]. 中华胃肠外科杂志, 2014, 0(4): 317-320 |
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| 作者姓名： | 潘志忠 伍小军 姜武 |
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| 作者单位： | 中山大学肿瘤防治中心华南肿瘤学国家重点实验室,广州510060 |
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| 摘 要： | 随着分子靶向治疗在胃肠间质瘤（GIST）领域取得的巨大成功，GIST中的分子事件引起了广泛关注。研究发现．GIST患者的药效反应和预后与其本身的基因改变，即分子分型密切相关。借助分子分型，将肿瘤生物学行为相似的患者归为同一组别，进而制定相应的治疗策略，可能会成为今后GIST临床实践的重要模式。
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| 关 键 词： | 胃肠间质瘤 KIT基因 PDGFRA基因 分子分型 |
Role of molecular subtypes in gastrointestinal stromal tumors in a clinical setting |
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| Pan Zhizhong,Wu Xioojun,Jiang Wu. Role of molecular subtypes in gastrointestinal stromal tumors in a clinical setting[J]. Chinese journal of gastrointestinal surgery, 2014, 0(4): 317-320 |
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| Authors: | Pan Zhizhong Wu Xioojun Jiang Wu |
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| Affiliation: | . Department of Coloreetal Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Guangdong 510060, China |
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| Abstract: | Gastrointestinal stromal tumors （GIST） are known for their molecular alterations in KIT or PDGFR genes, and have become the paradigm of molecularly targeted therapies for solid tumors. Recent researches of genotype and phenotype demonstrate that molecular subtypes can predict the response to treatment with tyrosine kinase inhibitors and are related with prognosis. Different strategies will be recommended according to different molecular subtypes of GIST in the future for treatment optimization and individualization. |
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| Keywords: | Gastrointestinal stromal tumors GeneKIT Gene PDGFRA Molecular subtypes |
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