TTV感染与原发性肝癌关系的病例对照研究

目的：了解ＴＴＶ与ＨＰＣ的关系。方法：对８２例ＰＨＣ、４０例非肝癌恶性肿瘤病人（对照组１）、４０例正常人（对照组２）进行病例对照研究。结果：ＰＨＣ组中．ＨＢｓＡｇ、ＨＢｅＡｇ、ＨＢＶ－ＤＮＡ，、ＨＢＶ－Ｍ的阳性率分别为７５．６％，５１．２％、１９．５％、２８．９％、８２．９％。显著高于两组照组，ＴＴＶ－ＤＮＡ阳性率２６．８％（２２／８２）也显著高于两对照组。ＨＢＶＣ感染率（８２．９％（）显著高于Ｔ

A Control Study on Relationship between TTV Infection and Primary Hepatic Carcinoma

Aim: In order to understand the relationship of transfusion-transmitted virus (TTV) and primary hepatic carcinoma (PHC), Method: 82 patient with PHC, 40 with malignant tumours without evidence of liver involvement, and 40 normal controls were conducted by the case-control study. Results: Among patients with PHC the positive rates of HBsAg, anti-HBe, HBeAg, HBV-DNA, HBV-M were 75.6%, 51.2%, 19.5%, 28.0%, 82.9%, respectively. All of markers were higher than those detected in the other two groups. The positive rates of TTV in PHC patients were 26. 8% (22/82), that was higher than that of the other two groups, the positive rates of HBV-M (82. 9%) was higher than that of TTV-DNA. In the 14 of PHC patients who were no HBV infection, the positive rates of TTV-DNA was 35.7% (5/14). If we put the PHC patients at different age levels according to the status of HBV and TTV infection, there is tendency of early occurence of this heogrowth in simple HBV or TTV infection and also HBV and TTV mixed infections. In simple HBV and mixed with TTV patients, the Odds Ratio were higher than two control groups's. Conclusion : There results indicated that in Guangdong province, TTV infection might relate to PHC and play a possible role in the etiology of PHC, But HBV infection is still the major etiological factor.