抗RA33抗体水平在类风湿关节炎和系统性红斑狼疮诊断中的意义

目的探讨抗RA33抗体水平在类风湿关节炎(RA)和系统性红斑狼疮(SLE)疾病诊断中的意义。方法采用定量ELISA双抗夹心法检测了140例RA患者、90例SLE患者、70例非SLE和非RA患者和40例正常人血清中抗RA33抗体的水平。结果SLE患者组与RA组抗RA33抗体水平分别为0～102.8U/ml和0～162.5U/ml,正常对照组为0～21.2U/ml。SLE患者组和RA患者组抗RA33抗体敏感性分别为21.1%(19/90)和34.3%(48/140),特异性分别为76.2%和86.9%。SLE患者组和RA患者组与正常对照组抗RA33抗体结果比较差异有显著性(P<0.01),SLE患者组血清抗RA33抗体结果与RA患者组比较差异有显著性(P<0.05)。结论抗RA33抗体检测在SLE和RA中具有良好的敏感性及特异性,可视为RA早期诊断新的血清学指标,抗RA33抗体阳性提示SLE患者已经有骨或关节的损害。

The diagnostic significance of anti-RA33 antibody levels in patients with RA or SLE

Objective To explore the diagnostic signigicance of anti-RA33antibody levels in patients with rheumatoid arthritis(RA)or systemic lupus erythematosus(SLE).Methods By using ELISA method the serum concentration of anti-RA33antibody was detected in140RA patients,90SLE patients,70neither SLE nor RA patients and40normal people.Results The concentration of anti-RA33antibody in SLE patients was0-102.8U/ml,and in RA patients was0-162U/ml,while in normal people was only0-21.2U/ml.The sensitivity of this antibody in SLE and RA patients was21.1%(19/90)and34.3(48/140),and the specificity was76.2%and86.9%.The results difference between SLE patients and normal people,RA patients and normal people had notible significance(P<0.01),so did that between SLE patients and RA patients(P<0.05).Conclusion Anti-RA33antibody detection has good sensitivity and specificity in SLE patients and RA patients,it can be used as a new serum index for diagnosing RA in early period.Positive anti-RA33antibody suggects that bone or arthrosis in SLE patients had be injuried.