Claudin-4和PTEN在子宫内膜癌中的表达及其意义

 目的 探讨claudin-4和PTEN在子宫内膜癌中的表达、意义及两者之间的关系。 方法 采用免疫组化SP法检测75例子宫内膜癌、35例不典型增生和28例增生期子宫内膜的claudin-4和PTEN表达。 结果 从正常增生期子宫内膜、非典型增生、到宫内膜癌，claudin-4阳性表达呈逐渐增高趋势，组间差异有统计学意义（P<0.05）；PTEN阳性表达呈下降趋势，组间差异有统计学意义（P<0.05）。claudin 4高表达与癌组织肌层浸润有关（P<0.05），与组织分级、手术病理分期、组织学类型及有无淋巴结转移无关；PTEN低表达与肌层浸润有关（P<0.05），与组织分级、手术病理分期、组织学类型、及有无淋巴结转移无关。claudin 4与PTEN呈负相关（r= 0.36, P<0.05）。 结论 claudin-4高表达可能促进了子宫内膜癌发生和发展，PTEN低表达在这一过程中可能具有协同作用。

Expression and Significance of claudin-4 and PTEN in Endometrial Carcinoma

Objective To investigate the expression and significance of claudin-4 and PTEN in endomentri-oid adenocarcinorna. Methods Immunohistochernistry was applied to detect the expression of claudin-4 and PTEN in 75 cases of endomentrioid adenoearcinomas,35 dysplasias and 28 proliferating endometria. Remits From proliferative endometrium, endometrial dysplasia to endometrial the positive expression of claudin-4 increased gradually. There was a significant difference between groups (P<0.05). The posi-tive expression of PTEN in three groups showed an increasing trend. The difference was significant (P< 0.05). The overexpression of claudin-4 was correlated to myometrialinvasion(P<0.05), but not to histo-logical grade invasion(P>0.05), histological grade pathologic stage lymph node metastasis nor histologi-cal type;the hypoexpression of PTEN was correlated to myometrialinvasion(P<0.05), not tO those of the others. Negative correlation was found between elaudin-4 and PTEN(r=-0.36, P<0.05) . Conclu-sion Overexpression of claudin-4 may be involved in carcinogenesis and development of endometrioid ad-enocarcinoma,and hypoexpression of PTEN may contribute to these process.