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| 5-氟尿嘧啶明胶微球在犬颌面部动脉栓塞的药代动力学研究 | |
| 引用本文： | 马工,封兴华,刘芳,孟庆江. 5-氟尿嘧啶明胶微球在犬颌面部动脉栓塞的药代动力学研究[J]. 中国现代医学杂志, 2003, 13(22): 63-65 |
| 作者姓名： | 马工 封兴华 刘芳 孟庆江 |
| 作者单位： | 1. 第四军医大学口腔医学院颌面外科,西安,710032 2. 空军总医院检验科 3. 西安第四军医人学口腔医学院放射科,710032 |
| 摘 要： | 目的：比较两种介入治疗方法的5-氟尿嘧啶明胶微球在体内的药物释放特点。方法：在不同时间点取血样并用紫外分光光度法测定局部组织及外周静脉血的血药浓度，并进行药代动力学分析。结果：动脉灌注法可以产生局部较高的血药浓度，但维持时间较短；使用氟尿嘧啶明胶微球进行栓塞可以在较小的用药剂量上在局部维持相对较长时间的较高的血药浓度。结论：氟尿嘧啶明胶微球进行动脉栓塞可以显著降低全身血药浓度及用药剂量，达到肿瘤靶向治疗的目的。 |
| 关 键 词： | 微球 明胶 氟尿嘧啶 药物浓度 栓塞 |
| 文章编号： | 1005-8982-(2003)22-0063-03 |
| 修稿时间： | 2002-11-17 |
Pharmacokinetics of 5-Fu gelatin microsphere after embolization in maxillofacial artery of dog |
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| MA Qin_qin,FENG Xing_hua,LIU Fang,MENG Qing_jiang. Pharmacokinetics of 5-Fu gelatin microsphere after embolization in maxillofacial artery of dog[J]. China Journal of Modern Medicine, 2003, 13(22): 63-65 | |
| Authors: | MA Qin_qin FENG Xing_hua LIU Fang MENG Qing_jiang |
| Affiliation: | MA Qin_qin,FENG Xing_hua,LIU Fang,MENG Qing_jiang. Department of Oral and Maxillofacial Surgery,Stomatological College,Fourth Military Medical University,Xi'an,710032 |
| Abstract: | Objective:Studies were conducted in dog to evaluate the pharmacokinetics of 5-Fu gelatin microsphere(FGM) by the analysis of different employment methods of 5-Fu.Methods:Blood samples were tested at different time and analyzed pharmacokinetically.Results:A transient higher blood drug concentration(BDC) was produced by artery perfusion. Small dosage of FGM by method of artery embolization could produce a high BDC level for a longer time in local region.Conclusions:External carotid artery embolization with FGM ,which significantly reduced the circulating drug level and employment dosage,could achieve the purpose of targeted tumor therapy. |
| Keywords: | Microsphere Gelatin Fluorouracii Drug concentration Embolization |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |