抗人类免疫缺陷病毒蓝藻蛋白-N研究进展

蓝藻抗病毒蛋白 N (cyanovirin N ,CV N )是一种从椭孢念珠藻 (Nostocelliposporum )中分离出的抗病毒活性蛋白 ,能够有效地抑制多个亚型的人类免疫缺陷病毒Ⅰ (HIV Ⅰ ) ,Ⅱ (HIV Ⅱ )以及猴免疫缺陷病毒 (SIV )。CV N的上述特性使它可能成为艾滋病 (AIDS)的潜在高效治疗药物。大量研究证明 ,CV N与包膜糖蛋白 12 0 (GP12 0 )具有高度亲和性并能够阻断由包膜蛋白介导的细胞融合过程从而阻止病毒的扩散。CV N的出现标志着天然多肽抗艾滋病药物时代的到来

Advancement in research of cyano-virin-N, a HIV-inactivating protein

Cyanovirin N(CV N), a 11KD anti HIV polypeptide, was originally isolated from blue green algae Nostoc elliposporum . The most special character of CV N is that it can markedly suppress the activity of several substrains of HIV Ⅰ ,HIV Ⅱ and SIVs. Such suppression of HIV makes CV N an extraordinary valuable potential medicine for AIDS treatment. Researchers have proved that CV N has a specific affinity to GP120 and can subsequently interfere the cell fusion mediated by it, which causes the further infection of HIV among cells. CV N defines a new strategy of AIDS treatment through natural viruscidous peptide.