Solubility of selected derivatives of 1,4-benzodiazepin-2-one in solid dispersions in PEG 6000

Pharmaceutical availability of diazepam, oxazepam and nitrazepam from solid dispersions of PEG 6000 have been studied in comparison with corresponding physical mixtures and pure benzodiazepines. Selected derivatives of 1,4-benzodiazepin-2-one are poorly water soluble drugs. The aim of this work was to report the properties of diazepam- and nitrazepam-PEG 6000 solid dispersions. Differential scanning calorimetry (DSC) and X-ray diffraction were used to characterize the solid dispersions. The effect of PEG 6000 on the dissolution of selected derivatives of 1,4-benzodiazepin-2-one was investigated. The dissolution of diazepam, oxazepam and nitrazepam from its solid dispersions increased in the presence of PEG 6000.