Effect of auranofin on autoimmune disease in a mouse model |
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| Authors: | T Fujitsu S Sakuma N Seki H Senoh J Mori H Kikuchi |
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| Affiliation: | 1. Niigata Prefectural Sake Research Institute, 2-5932-133 Suido-cho, Chuoh-ku, Niigata 951-8121, Japan;2. Department of Applied Biological Chemistry, Faculty of Agriculture, Niigata University, 2-8050 Ikarashi, Nishi-ku, Niigata 950-2181, Japan;1. Department of Biochemistry, Hoshi University School of Pharmacy, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan;2. Department of Microbiology, Hoshi University School of Pharmacy, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan;3. Department of Clinical and Analytical Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan;4. SBI Pharmaceuticals Co., Ltd., 1-6-1, Roppongi, Minato-ku, Tokyo, 106-6020, Japan;5. Division of Glycobiologics, Intractable Disease Research Center, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan;1. Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, Japan;2. Amine Pharma Research Institute, Chiba, Japan;3. Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan;1. Key Laboratory of Synthetic Rubber, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China;2. Changchun Center of Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China;3. University of Chinese Academy of Sciences, Beijing 100039, China |
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| Abstract: | The effect of an oral gold preparation, auranofin, on the autoimmune disease mouse MRL/l was examined. Oral administration of auranofin on consecutive days from 6 weeks of age reduced anti-DNA antibody production, IgM rheumatoid factor production, hypergammaglobulinemia, polyclonal B cell activation and renal disease, but did not prevent massive lymphadenopathy or restore the low level of either IL-2 production or mitogen response associated with 1pr gene. In contrast to the effect on autoantibody production, little suppressive activity on the immune response to exogenous antigen SRBC was observed. These results indicate that autoimmune disease in MRL/l mice can be prevented without abrogation of T cell abnormalities and that autoimmune-selective suppression can be induced by chemical compound(s) like auranofin. |
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