| Eeffects of nerve growth factor on N—methyl—D—asparate receptor 1 after spinal cord injury in rats |
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| 引用本文： | 曹晓建 汤长华 等. Eeffects of nerve growth factor on N—methyl—D—asparate receptor 1 after spinal cord injury in rats[J]. 中华创伤杂志(英文版), 2002, 5(4): 228-231 |
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| 作者姓名： | 曹晓建 汤长华 等 |
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| 作者单位： | DepartmentofOrthopedics,FirstAffiliatedHospital,NanjingMedicalUniversity,Nanjing210029,China |
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| 摘 要： |
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| 关 键 词： | 脊髓损伤 N－甲基－D－天冬氨酸受体1 神经生长因子 |
Effects of nerve growth factor on N-methyl-D-asparate receptor 1 after spinal cord injury in rats. |
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| Xiaojian Cao,Changhua Tang,Yongxiang Luo. Effects of nerve growth factor on N-methyl-D-asparate receptor 1 after spinal cord injury in rats.[J]. Chinese journal of traumatology, 2002, 5(4): 228-231 |
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| Authors: | Xiaojian Cao Changhua Tang Yongxiang Luo |
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| Affiliation: | Department of Orthopedics, First Affiliated Hospital, Nanjing Medical University, China. |
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| Abstract: | OBJECTIVE: To explore the effects of the nerve growth factor (NGF) on N-methyl-D-asparate receptor 1 (NMDAR 1) after spinal cord injury. METHODS: Spinal cord injury of Wistar rats was performed with Allen's method by a 10 gx2.5 cm impact on the posterior T8 spinal cord. NGF was given to the rats of the treatment group via subarachnoid space tube at once, 2, 4, 8, 12 and 24 hours after spinal cord injury, respectively. The expression of NMDAR1 mRNA in spinal cord was detected by in situ hybridization. RESULTS: Rare expression sequence of NMDAR1 mRNA was found in rat spinal cord of the normal group. A strong expression sequence of NMDAR1 mRNA was found in rat spinal cord of the normal saline group. The expression of NMDAR1 mRNA in the NGF group was significantly decreased as compared with that in the normal saline group (P=0.01). CONCLUSIONS: NGF can relieve damage of injured spinal cord by prohibiting the expression of NMDAR1 mRNA. |
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