| 脑内胰岛移植治疗Ⅰ型糖尿病 |
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| 引用本文： | 董砚虎,钱捷,王善言,张振兴,逄力男,孔凡介,张贺,韩卫,张增富,王伯孝,王永和,王寿先,季祥武,钱薇,刘登岳,马志根,白林,刘俊芝,赵鑫.脑内胰岛移植治疗Ⅰ型糖尿病[J].中华内分泌代谢杂志,1989(4). |
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| 作者姓名： | 董砚虎 钱捷 王善言 张振兴 逄力男 孔凡介 张贺 韩卫 张增富 王伯孝 王永和 王寿先 季祥武 钱薇 刘登岳 马志根 白林 刘俊芝 赵鑫 |
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| 作者单位： | 山东潍坊市人民医院
(董砚虎，钱捷，王善言，张振兴，逄力男，孔凡介，张贺，韩卫，张增富，王伯孝，王永和，王寿先，季祥武，钱薇，刘登岳，马志根)，山东潍坊医学院组胚室
(白林)，驻潍54960部队医院外科
(刘俊芝)，驻潍54960部队医院外科(赵鑫) |
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| 摘 要： | 本研究采用培养的人胎儿胰岛组织脑内移植治疗Ⅰ型糖尿病患者10例,其中7例已完全撤离胰岛素治疗达2～13个月,2例每日胰岛素剂量较移植前分别减少37％和64％,病情控制良好,无效者1例。本研究结果表明,脑内胰岛移植治疗Ⅰ型糖尿病临床效果显著,移植物可能在患者脑内成活。
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| 关 键 词： | Ⅰ型糖尿病 脑内胰岛移植 免疫特许区 |
INTRACEREBRAL PANCREAS ISLET TRANSPLANTATION FOR THE TREATMENT OF TYPE I DIABETES MELLITUS |
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| Dong Yan-hu et al.
Weifang People's Hospital,Shandong.INTRACEREBRAL PANCREAS ISLET TRANSPLANTATION FOR THE TREATMENT OF TYPE I DIABETES MELLITUS[J].Chinese Journal of Endocrinology and Metabolism,1989(4). |
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| Authors: | Dong Yan-hu
Weifang People's Hospital Shandong |
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| Abstract: | Ten cases of type I diabetes mellitus were treated with intracerebral pancreas islet transplantation. In 7 cases insulin has been totally stopped for 2 to 13 months, in other 2 cases the dosages of insulin had a decrease of 37% and 64% than that before transplantation respectively, and good control was achieved in those 9 patients. Only one case had not any improvement. The results showed that it is an effective therapy for type I diabetes mellitus and indicated that the pancreas islet was survived in patient's cerebrum and secreted insulin. No evidence of immunological rejection was found. Long-term follow-up is necessary to find how long the allogenic graft can survive. |
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| Keywords: | Intracerebral pancreas islet transplantation Type I diabetes mellitus Immunologically privilegd site |
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