In vitro antibacterial activity and beta-lactamase stability of CP-70,429 a new penem antibiotic. |
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Authors: | M Minamimura Y Taniyama E Inoue S Mitsuhashi |
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Abstract: | In in vitro susceptibility tests, the new penem CP-70,429 showed potent antibacterial activity against gram-positive and gram-negative bacteria except Pseudomonas aeruginosa and Xanthomonas maltophilia. CP-70,429 was stable to various types of beta-lactamases except for the enzyme from X. maltophilia and was 16- to 128-fold more active than the other compounds against beta-lactamase-producing strains of Enterobacter cloacae and Citrobacter freundii. |
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