Effect of phosphoramidon - a selective enkephalinase inhibitor - on nociception and behaviour |
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| Authors: | J Rupreht O E Ukponmwan P V Admiraal M R Dzoljic |
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| Institution: | 1. Department of Anaesthesiology, Faculty of Medicine, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam The Netherlands;2. Department of Pharmacology, Faculty of Medicine, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam The Netherlands;3. St. Hippolytus Ziekenhius, Delft The Netherlands |
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| Abstract: | Phosphoramidon (100-350 micrograms i.c.v.), a selective enkephalinase inhibitor, induced in the rat a decrease of nociception to pressure stimulation without evident respiratory depression. In addition, intensive behavioural changes such as grooming (licking the fur, face washing and scratching), mounting behaviour and wet dog shakes were observed. Naltrexone pretreatment (1 mg/kg i.p.) caused a significant decrease in the phosphoramidon-induced nociception and behavioural changes. Puromycin (30 micrograms i.c.v. or 7.5 mg/kg i.p.) caused no changes in nociception or behaviour. |
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| Keywords: | phosphoramidon enkephalinase analgesia grooming mounting wet-dog-shakes |
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